Inhalation toxicity of vinyl chloride and Vinylidene chloride
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منابع مشابه
Inhalation toxicity of vinyl chloride and Vinylidene chloride*
Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month, mice exposed to 1000, 250, or 50 ppm of VC became lethargic, lost weight quickly, and died. Only a few mice exposed to 50 ppm survived for 12 months. Pulmonary macrophage count was elevated in some mi...
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Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the original substance. Comparative investigation of the biological fate of vinyliden...
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In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly include the liver, brain and the lung, and probably the lymphohematopoietic system. The evidence fo...
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Dear Sir: The recent article by McKenna et al. (1) on phar-macokinetics of vinylidine chloride (VDC) in the rat has evoked a number of thoughts. These relate both to one detail of data presentation from the excellent experimental studies and to the general role of pharmacokinetics in supporting risk assessment from high dose studies in mammals. The detail concerns Figure la (Figure 2 of the McK...
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The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inha...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1977
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.772125